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[Virilizing ovarian tumor in an adolescent]
Y François1, P Berlier, P Chatelain
1Service de chirurgie, Hôpital Claude-Bernard, Oullins, France.
Pediatrie
|January 1, 1990
Summary
A rare ovarian tumor caused virilization and amenorrhea in a 13-year-old girl. Surgical removal led to polycystic changes in the remaining ovary, highlighting the impact of tumoral hyperandrogeny.
Area of Science:
- Reproductive Endocrinology
- Gynecologic Oncology
- Pediatric Endocrinology
Background:
- Secondary virilization and amenorrhea in adolescents warrant thorough investigation.
- Ovarian tumors can present with significant hormonal disturbances.
Observation:
- A 13-year-old girl presented with secondary virilization, amenorrhea, and an abdominal mass.
- Markedly elevated plasma testosterone and androstenedione levels were noted.
- A large, macrocystic granulosa cell tumor was surgically removed from the ovary.
Findings:
- Histologic examination confirmed a non-juvenile type macrocystic granulosa cell tumor.
- Following tumor removal and ipsilateral ovariectomy, the contralateral ovary exhibited polycystic changes.
- Tumoral hyperandrogeny is implicated in the development of contralateral polycystic ovarian changes.
Implications:
- This case underscores the importance of considering ovarian tumors in adolescent hyperandrogenism.
- Tumoral hyperandrogeny can induce secondary polycystic ovarian changes.
- Understanding these mechanisms is crucial for managing similar complex endocrine-neoplastic presentations in pediatric patients.