Vieillardiixanthone B.

Area of Science:

• Natural Product Chemistry
• Organic Chemistry
• Crystallography

Background:

• Cratoxylum formosum ssp. pruniflorum is a plant source of bioactive compounds.
• Xanthones are a class of organic compounds with diverse biological activities.
• Understanding the structural and chemical properties of natural products is crucial for drug discovery.

Purpose of the Study:

• To isolate and characterize a novel xanthone from the roots of Cratoxylum formosum ssp. pruniflorum.
• To determine the three-dimensional structure and intermolecular interactions of the isolated xanthone.
• To contribute to the chemical knowledge of the Cratoxylum genus.

Main Methods:

• Isolation of the title compound using chromatographic techniques.
• Structure elucidation using spectroscopic methods (e.g., NMR, Mass Spectrometry).
• Single-crystal X-ray diffraction analysis to determine the molecular and crystal structure.

Main Results:

• The title compound, 1,5-dihydroxy-3,6-dimethoxy-4-(2-methyl-but-3-en-2-yl)-9H-xanthen-9-one (C20H20O6), was successfully isolated and identified.
• X-ray diffraction revealed a nearly planar xanthone core with specific substituent conformations.
• Intramolecular hydrogen bonds (S(5) and S(6) motifs) and intermolecular interactions (O-H⋯O, C-H⋯O, π-π stacking) were characterized in the crystal lattice.

Conclusions:

• The study reports a new xanthone derivative from Cratoxylum formosum.
• The detailed structural analysis provides insights into the stereochemistry and intermolecular forces governing the compound's solid-state arrangement.
• This research expands the understanding of xanthone diversity and their structural characteristics.