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Updated: Jun 1, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
4-Chloro-N'-(2-methoxy-benzyl-idene)benzohydrazide
1College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, People's Republic of China.
This study details the synthesis and crystal structure of a novel organic compound. The research highlights the formation of hydrogen bonds and molecular chains within the crystal lattice.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzaldehyde derivatives are crucial in synthesizing various organic compounds.
- Hydrazide compounds exhibit diverse biological and chemical properties.
Purpose of the Study:
- To synthesize a novel organic compound with the molecular formula C(15)H(13)ClN(2)O(2).
- To elucidate the crystal structure and intermolecular interactions of the synthesized compound.
Main Methods:
- Chemical synthesis involving the reaction of 3-methoxy-benzaldehyde and 4-chloro-benzo-hydrazide in methanol.
- X-ray crystallography to determine the unit cell and molecular arrangement.
- Analysis of hydrogen bonding (N-H⋯O and N-H⋯N) and dihedral angles.
Main Results:
- Successful synthesis of the target compound C(15)H(13)ClN(2)O(2).
- The asymmetric unit contains two unique molecules linked by hydrogen bonds.
- Dihedral angles between benzene rings are 77.3(1)° and 44.1(1)°.
- Intermolecular N-H⋯O hydrogen bonds form chains along the a-axis in the crystal structure.
Conclusions:
- The study provides a detailed structural characterization of a new organic compound.
- The findings reveal specific hydrogen bonding patterns and crystal packing, contributing to the understanding of structure-property relationships.
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