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Updated: Jun 1, 2026

Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
2-(1H-Benzotriazol-1-yl)acetohydrazide.
1Department of Materials Science and Chemical Engineering, Taishan University, 271021 Taian, Shandong, People's Republic of China.
Researchers synthesized a novel compound, C(8)H(9)N(5)O, using ethyl 2-(benzotriazol-1-yl)acetate and hydrazine hydrate. The study reveals electronic delocalization within the amide group and intermolecular hydrogen bonding in its crystal structure.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Benzotriazole derivatives are important in medicinal chemistry.
- Understanding molecular structure and bonding is crucial for chemical synthesis.
Purpose of the Study:
- To synthesize and characterize a novel compound with the chemical formula C(8)H(9)N(5)O.
- To investigate the structural properties, including bond lengths and intermolecular interactions, of the synthesized compound.
Main Methods:
- Synthesis via the reaction of ethyl 2-(benzotriazol-1-yl)acetate with hydrazine hydrate in ethanol.
- Analysis of the crystal structure to determine molecular geometry and bonding.
Main Results:
- Successful synthesis of the target compound C(8)H(9)N(5)O.
- Observation of a short C-N bond (1.3283 Å) in the amide group, indicating electronic delocalization.
- Identification of infinite chains formed by intermolecular O-H⋯N hydrogen bonding in the crystal structure.
Conclusions:
- The synthesized compound exhibits electronic delocalization within its amide group.
- Intermolecular hydrogen bonding plays a significant role in the crystal packing of the compound.
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