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Updated: Jun 1, 2026

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Separation and Fractionation of Culture Filtrate Proteins (CFPs) from Mycobacterium tuberculosis

Published on: July 11, 2025

MTB-PCDB: Mycobacterium tuberculosis proteome comparison database.

Lingaraja Jena¹, Gauri Wankhade, Satish Kumar

¹Bioinformatics Centre, JB Tropical Disease Research Centre, Mahatma Gandhi Institute of Medical Sciences, Sevagram (Wardha) 442102, Maharashtra, India.

|May 18, 2011

Summary

This summary is machine-generated.

The Mycobacterium tuberculosis Proteome Comparison Database (MTB-PCDB) offers proteome data for five M. tuberculosis strains. This resource aids in discovering new TB drugs, vaccines, and biomarkers through comparative proteomic analysis.

Keywords:

drug resistance proteome comparison proteomic variation tuberculosis virulence

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Area of Science:

Genomics
Proteomics
Bioinformatics

Background:

The Mycobacterium tuberculosis Proteome Comparison Database (MTB-PCDB) integrates proteome sequence comparison data for five fully sequenced strains of M. tuberculosis.
It hosts 40,252 protein sequence comparisons from inter-strain analysis.

Purpose of the Study:

To provide a centralized online platform for comparative proteomic analysis of M. tuberculosis strains.
To facilitate the discovery and development of novel tuberculosis (TB) drugs, vaccines, and biomarkers.

Main Methods:

Comparative analysis of proteome sequences from five M. tuberculosis strains (H37Rv, H37Ra, CDC 1551, F11, KZN 1435).
Development of integrated tools for searching, browsing, analyzing, and downloading proteomic data.
Utilizing MTB H37Rv as the reference strain for comparisons.

Main Results:

Identified 2,373 proteins that are identical across all five M. tuberculosis strains analyzed.
Generated a comprehensive dataset of 40,252 protein sequence comparisons.

Conclusions:

MTB-PCDB serves as a unique discovery platform for comparative proteomics in M. tuberculosis.
The database supports research into virulence, drug resistance, and the development of new TB interventions.