Eggerthella lenta bacteremia in a Crohn's disease patient after ileocecal resection

Venkata R Thota1, Sunil Dacha, Aparna Natarajan

  • 1Department of Medicine, Saint Joseph Hospital, Chicago, IL 60657, USA. drthota@gmail.com

Future Microbiology
|May 19, 2011
PubMed

Insights

Eggerthella lenta bacteremia is rare but significant, often linked to gastrointestinal issues. This case highlights a young Crohn's disease patient experiencing this infection post-surgery.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Eggerthella lenta is a common gut bacterium.
  • Bacteremia caused by E. lenta is rare and clinically significant.
  • Gastrointestinal diseases and malignancy are typical causes of E. lenta bacteremia.

Observation:

  • Eggerthella species are found in patients with inflammatory bowel disease.
  • E. lenta bacteremia has not been previously reported in Crohn's disease patients.
  • A young African-American female with Crohn's disease developed E. lenta bacteremia.

Findings:

  • The patient underwent ileocaecal resection.
  • Post-surgery, the patient developed E. lenta bacteremia.
  • This represents a novel association between Crohn's disease, surgery, and E. lenta bacteremia.

Implications:

  • This case expands the understanding of E. lenta as a potential pathogen in immunocompromised patients.
  • Highlights the importance of considering E. lenta in patients with inflammatory bowel disease and recent gastrointestinal surgery.
  • Suggests a potential link between gut dysbiosis in Crohn's disease and invasive E. lenta infections.

Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Amebiasis01:28

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Microbiota of the Large Intestine01:27

Microbiota of the Large Intestine

The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...