Related Experiment Video
Updated: Jun 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
1,3-Dibenzyl-1,2,3,4-tetra-hydro-quinazoline-2,4-dione
Abstract:
The asymmetric unit of the title compound, C(22)H(18)N(2)O(2), contains two independent mol-ecules, which differ in the orientations of the benzyl groups with respect to the planar (r.m.s. deviations of 0.031 and 0.020 Å) quinazoline-2,4-dione skeletons [dihedral angles of 73.97 (4) and 70.07 (4)° in the first mol-ecule and 75.63 (4) and 63.52 (3)° in the second]. The crystal structure is stabilized by weak inter-molecular C-H⋯O and C-H⋯π interactions and aromatic π-π stacking inter-actions [centroid-centroid distance = 3.735 (2) Å].
Related Concept Videos
Radical Chain-Growth Polymerization: Overview
Diazonium Group Substitution: –OH and –H
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox property is crucial in...
Structure of Conjugated Dienes
Conjugated dienes are compounds characterized by the presence of alternating double and single bonds. In a conjugated system like 1,3-butadiene, the unhybridized 2p orbital on each carbon overlaps continuously, allowing the π electrons to be delocalized across the entire molecule. In contrast, this type of overlap does not occur in cumulated and isolated dienes, such as 2,3-pentadiene and 1,4-pentadiene, respectively. Instead, the π electrons remain localized between the double...

