Related Experiment Video
Updated: Jun 1, 2026
11:04
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
Published on: June 13, 2022
4-Allyl-6-bromo-2-phenyl-4H-imidazo[4,5-b]pyridine monohydrate
Abstract:
In the mol-ecule of the title compound, C(15)H(12)BrN(3)·H(2)O, the phenyl ring is coplanar with the imidazopyridine ring system [dihedral angle = 0.4 (1)°]. The water mol-ecule is disordered over two positions with occupancies of 0.58 (1) and 0.42 (1), and it is linked to the main mol-ecule via an O-H⋯N hydrogen bond.
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Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...