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Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives

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(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate.

¹School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|May 19, 2011

Summary

This study details the crystal structure of a hydrazone molecule, revealing its near-planar geometry and trans configuration. Hydrogen bonds in the crystal lattice link benzohydrazide and methanol molecules into chains.

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Area of Science:

Organic Chemistry
Crystallography

Background:

Hydrazone derivatives are important in medicinal chemistry and materials science.
Understanding the solid-state structure of organic molecules is crucial for predicting their properties.

Purpose of the Study:

To elucidate the crystal structure and intermolecular interactions of a specific hydrazone compound.

Main Methods:

Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
Analysis of bond lengths, bond angles, and hydrogen bonding patterns was performed.

Main Results:

The hydrazone molecule is nearly planar with a dihedral angle of 1.2(4)° between the benzene rings.
The molecule adopts a trans configuration around the central methylidene unit.
Intermolecular hydrogen bonds (O-H⋯O, O-H⋯N, N-H⋯O) form chains along the crystal's a axis.

Conclusions:

The crystal packing is dominated by hydrogen bonding interactions between benzohydrazide and methanol moieties.
The planar and trans configuration may influence the compound's electronic and physical properties.