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Updated: Jun 1, 2026
08:43
Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(E)-4-Meth-oxy-N'-(4-nitro-benzyl-idene)benzohydrazide methanol monosolvate
1School of Chemical Engineering, University of Science and Technology Liaoning, Anshan 114051, People's Republic of China.
Summary
This study details the crystal structure of a hydrazone molecule, revealing its near-planar geometry and trans configuration. Hydrogen bonds in the crystal lattice link benzohydrazide and methanol molecules into chains.
Area of Science:
- Organic Chemistry
- Crystallography
Background:
- Hydrazone derivatives are important in medicinal chemistry and materials science.
- Understanding the solid-state structure of organic molecules is crucial for predicting their properties.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of a specific hydrazone compound.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and hydrogen bonding patterns was performed.
Main Results:
- The hydrazone molecule is nearly planar with a dihedral angle of 1.2(4)° between the benzene rings.
- The molecule adopts a trans configuration around the central methylidene unit.
- Intermolecular hydrogen bonds (O-H⋯O, O-H⋯N, N-H⋯O) form chains along the crystal's a axis.
Conclusions:
- The crystal packing is dominated by hydrogen bonding interactions between benzohydrazide and methanol moieties.
- The planar and trans configuration may influence the compound's electronic and physical properties.
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