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Reduction of hydrazines to amines with aqueous solution of titanium(III) trichloride

Yan Zhang1, Qiang Tang, Meiming Luo

  • 1Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.

Organic & Biomolecular Chemistry
|May 21, 2011
PubMed

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Nitriles to Amines: LiAlH4 Reduction

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Amides to Amines: LiAlH4 Reduction01:20

Amides to Amines: LiAlH4 Reduction

Amide reduction with strong reducing agents like lithium aluminum hydride proceeds through a nucleophilic acyl substitution to form amines. Primary, secondary, and tertiary amides yield primary, secondary, and tertiary amines, respectively.
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