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Updated: Jun 1, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Chorio-amnionitis: clinical and biological aspects--medicolegal implications]

B Bessières1, P Bernard

  • 1Histo-embryologie et cytogénétique, CHU Necker, 149, rue de Sèvres, 75015 Paris, France.

Gynecologie, Obstetrique & Fertilite
|May 24, 2011
PubMed

Insights

Chorioamnionitis increases fetal cerebral palsy risk fivefold. A 2011 protocol addresses prevention and treatment for premature rupture of membranes, while French data highlights maternal risks and medicolegal considerations.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Medicine
  • Infectious Diseases

Context:

  • Chorioamnionitis, an infection of the fetal membranes and amniotic fluid, poses significant risks to both mother and fetus.
  • Premature rupture of membranes is a critical condition where timely intervention is crucial.

Purpose:

  • To outline fetal and maternal risks associated with chorioamnionitis.
  • To present a 2011 protocol for managing chorioamnionitis in cases of premature rupture of membranes, considering gestational age.
  • To analyze maternal risks using French statistical data (2001-2006) and discuss medicolegal implications.

Summary:

  • Fetal risks include a fivefold increase in cerebral palsy rates.
  • Maternal risks were assessed through a French statistical survey from 2001 to 2006.
  • The study emphasizes placental investigations and bacteriological tests due to medicolegal implications.

Impact:

  • Highlights the critical need for prompt diagnosis and management of chorioamnionitis to mitigate severe fetal complications like cerebral palsy.
  • Informs clinical practice regarding the prevention and treatment protocols for chorioamnionitis in premature rupture of membranes.
  • Underscores the importance of thorough investigations and documentation for medicolegal purposes in obstetric infections.

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