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[Association of IL-1beta gene -31T/C polymorphism with chronic rhinosinusitis]
Nijun Chen1, Peihua Ni, Changping Cai
1Department of Otolaryngology, Ruijin Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
Objective:
To investigate the relationship between polymorphism of IL-1beta gene 31T/C and chronic rhinosinusitis.
Method:
One hundred and twenty-three patients with chronic rhinosinusitis and 239 healthy controls were collected to determine the genotypes by polymerase chain reaction-restriction fragment length polymorphism.
Result:
There was significant difference in genotype and allelic frequencies between the CRS and control group (P < 0.05). -31CC genotype was an independent risk factor with CRS (P < 0.05, OR = 1.639). There was no significant difference in TIgE and ECP among these genotypes (P > 0.05).
Conclusion:
IL-1beta gene 31CC genotype may be an independent risk factor with chronic rhinosinusitis.
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