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Prognostic-significance of multifocality in primary breast-cancer
A Morabito1, F Perrone, R Lauria
1UNIV NAPLES FEDERICO II,FAC MED,CATTEDRA ONCOL MED,I-80131 NAPLES,ITALY. UNIV NAPLES FEDERICO II,FAC MED,IST PATOL,I-80131 NAPLES,ITALY. UNIV NAPLES 2,FAC MED,CATTEDRA STAT MED & BIOMETRIA,I-80131 NAPLES,ITALY. CNR,CTR ELABORAZ DATI CLIN ONCOL MEZZOGIORNO,NAPLES,ITALY.
Multicentric breast cancer, where multiple tumors are present, is linked to a higher risk of relapse and death. Early detection and understanding multicentricity are crucial for improving breast cancer patient survival outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Pathology
Background:
- Multicentricity in primary breast cancer presents a complex challenge in treatment and prognosis.
- Understanding the implications of multiple tumor foci is essential for effective breast cancer management.
Purpose of the Study:
- To evaluate the impact of multicentricity in primary breast cancer on patient outcomes after mastectomy.
- To identify factors associated with multicentricity and its prognostic significance.
Main Methods:
- Retrospective analysis of 1336 consecutive patients undergoing radical or modified radical mastectomy.
- Assessment of tumor foci, including infiltrating and in situ growth patterns.
- Statistical analysis, including multivariate analysis, to determine prognostic factors.
Main Results:
- Multicentricity was observed in 11.7% of breast cancers (8.4% infiltrating, 3.3% in situ).
- Significant associations found between infiltrating multicentricity and lobular carcinoma, younger age (≤50 years), larger tumors, and positive axillary nodes.
- Shorter 5-year disease-free and overall survival rates were noted in patients with infiltrating multicentric primary tumors.
- Multivariate analysis confirmed infiltrating multicentric tumors as an independent negative prognostic factor.
Conclusions:
- Infiltrating multicentric primary breast tumors are associated with poorer prognoses.
- Multicentricity, particularly the infiltrating type, is a significant prognostic indicator in breast cancer patients post-mastectomy.
- Adjuvant therapy and other factors do not negate the adverse prognostic impact of infiltrating multicentricity.
