Primary amyloidosis presenting as "dropped head syndrome"
Miguel Chuquilin1, Muhammad Al-Lozi
1Department of Neurology, Washington University, 660 South Euclid Avenue, Box 8111, St. Louis, Missouri 63110, USA.
Muscle & Nerve
|May 25, 2011
Summary
Amyloidosis can cause dropped head syndrome, a rare condition characterized by neck extensor weakness. This case highlights the importance of considering amyloidosis in patients with unexplained neck weakness and carpal tunnel syndrome.
Area of Science:
- Neurology
- Pathology
- Rheumatology
Background:
- A 77-year-old male with a history of lymphoma presented with isolated neck extensor weakness.
- The patient also had a 2-year history of bilateral carpal tunnel syndrome (CTS).
Observation:
- Needle electromyography revealed myopathic changes.
- Biopsy of cervical paraspinal muscles demonstrated amyloid deposition within blood vessels.
Findings:
- The findings suggest a link between amyloid deposition and neck extensor weakness.
- Amyloidosis, specifically AL amyloidosis, can manifest with neuromuscular symptoms.
Implications:
- Amyloidosis should be included in the differential diagnosis for dropped head syndrome.
- This case underscores the diverse clinical presentations of amyloidosis and the need for a comprehensive diagnostic approach.
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