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Updated: Jun 1, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development.

Caroline Alayne Pearson¹, Kyoji Ohyama, Liz Manning

¹MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.

Development (Cambridge, England)

|May 26, 2011

Summary

This summary is machine-generated.

The chick infundibulum arises from two distinct cell groups. FGF signaling is crucial for the growth and development of these progenitor cells, which form the infundibulum.

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Last Updated: Jun 1, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

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Published on: November 14, 2013

In Vivo Targeting of Neural Progenitor Cells in Ferret Neocortex by In Utero Electroporation

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Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains

Published on: June 8, 2018

Area of Science:

Developmental Biology
Neuroendocrinology
Cell Biology

Background:

The infundibulum is a critical brain region connecting the nervous and endocrine systems for maintaining homeostasis.
Understanding the cellular origins and developmental mechanisms of the infundibulum is essential for comprehending its role in body regulation.

Purpose of the Study:

To elucidate the cellular origins and developmental pathways of the chick infundibulum.
To investigate the role of signaling pathways, particularly FGF signaling, in infundibulum development and progenitor cell maintenance.

Main Methods:

Tracing cell lineages to identify the progenitor populations contributing to the infundibulum.
Utilizing genetic markers (Fgf3, SOX3, Fgf10) and signaling pathway inhibitors (SHH, FGF) to study cell induction and maintenance.
Assessing the proliferative capacity and differentiation potential of identified progenitor cells through neurosphere assays.

Main Results:

The chick infundibulum originates from two distinct subsets of anterior ventral midline cells: one forming the posterior-ventral region and another migrating laterally to form a collar.
Collar cells are identified as Fgf3(+) SOX3(+) proliferating progenitors, whose induction depends on SHH signaling, while their maintenance requires FGF signaling.
These progenitor cells exhibit extended proliferation late into embryogenesis and can differentiate into various cell types, including hypothalamic neurons and Fgf10(+) anterior-dorsal infundibular cells.

Conclusions:

A subset of anterior floor plate-like cells gives rise to Fgf3(+) SOX3(+) progenitor cells, establishing a dual origin for infundibular cells.
FGF signaling plays a crucial role in sustaining the proliferation and growth of infundibular progenitor cells throughout embryogenesis.
This study reveals novel insights into the cellular basis of infundibulum development and highlights the importance of FGF signaling in regulating its extended growth.