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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Phase II Reactions: Acetylation Reactions01:24

Phase II Reactions: Acetylation Reactions

Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...

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A Rat Model of Compound Acne
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Published on: November 1, 2024

Acitretin revisited.

C W Lynde1, J N Kraft, C B Lynde

  • 1Division of Dermatology, University of Toronto, ON, Canada.

Skin Therapy Letter
|May 26, 2011
PubMed
Summary
This summary is machine-generated.

Acitretin is a valuable medication for various skin conditions, demonstrating efficacy and a manageable side-effect profile over two decades. This review covers its use, benefits, and potential drawbacks in dermatology.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Acitretin has been utilized for two decades in treating dermatologic conditions.
  • Understanding its therapeutic applications and safety is crucial for clinicians.

Purpose of the Study:

  • To review the established efficacy of acitretin in various skin diseases.
  • To outline the side-effect profile associated with acitretin therapy.
  • To provide guidance on the appropriate clinical approach for using acitretin.

Main Methods:

  • Literature review of studies on acitretin over the past 20 years.
  • Analysis of clinical trial data and observational studies.
  • Synthesis of evidence regarding efficacy and adverse events.

Main Results:

  • Acitretin demonstrates significant efficacy across a spectrum of dermatologic diseases.
  • The side-effect profile is well-characterized and generally manageable with monitoring.
  • Evidence supports specific approaches for optimizing acitretin use.

Conclusions:

  • Acitretin remains a key therapeutic agent in dermatology.
  • A thorough understanding of its efficacy and side effects guides safe and effective patient care.
  • Clinical protocols enhance the successful application of acitretin.