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Hybridization kinetics between immobilized double-stranded DNA probes and targets containing embedded recognition

Bryan A Baker1, Valeria T Milam

  • 1School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Dr. NW, Atlanta, GA 30332-0245, USA.

Nucleic Acids Research
|May 27, 2011
PubMed
Summary

We explored how DNA probe design affects strand displacement. Modifying probe affinity by changing length or mismatches tunes reaction speed, with longer targets showing slower but successful displacement.

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