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Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
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Catalysis for fluorination and trifluoromethylation.

Takeru Furuya1, Adam S Kamlet, Tobias Ritter

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Nature
|May 27, 2011
PubMed
Summary

Recent catalytic advances simplify adding fluorine to organic molecules. New reactions overcome challenges in forming carbon-fluorine bonds, enabling broader use of fluorinated compounds in pharmaceuticals and materials.

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