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Updated: Jun 1, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Contact sensitization in very young children.
Anna Belloni Fortina1, Ilaria Romano1, Andrea Peserico2
1Dermatology Unit, Department of Pediatrics, University of Padova, Padua, Italy.
Journal of the American Academy of Dermatology
|May 28, 2011
Summary
Allergic contact dermatitis is common in young children. Patch testing revealed high rates of sensitization to common allergens like nickel sulfate, suggesting its utility in diagnosing persistent cases.
Area of Science:
- Pediatric Dermatology
- Allergology
- Clinical Immunology
Background:
- Allergic contact dermatitis is a growing concern in pediatric populations.
- Early diagnosis and management are crucial for affected children.
Purpose of the Study:
- To assess the prevalence of contact sensitization in children under three years old with suspected allergic contact dermatitis.
- To identify common allergens responsible for sensitization in this age group.
Main Methods:
- A 6-year prospective study (2002-2008) involving 321 children under three years of age.
- Routine patch testing using a standard pediatric series of 30 allergens was performed.
Main Results:
- Over 62% of children tested showed at least one positive reaction to allergens.
- Nickel sulfate was the most frequent sensitizer (26.8%), followed by potassium dichromate and cocamidopropylbetaine.
- Contact sensitization prevalence was similar in children with and without atopic dermatitis.
Conclusions:
- A significant prevalence of contact sensitization exists in children under three years old.
- Patch testing is recommended for preschool children with persistent dermatitis unresponsive to standard treatments.
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