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Updated: Jun 1, 2026

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
Testosterone deficiency and risk factors in the metabolic syndrome: implications for erectile dysfunction
Andre T Guay1, Abdulmaged Traish
1Center for Sexual Function/Department of Endocrinology, Lahey Clinic, Northshore One Essex Center Drive, Peabody, MA 01960, USA. Andre.T.Guay@Lahey.org
Abstract:
The most common cause of erectile dysfunction (ED) is penile vascular insufficiency. This is usually part of a generalized endothelial dysfunction and is related to several conditions, including type 2 diabetes mellitus, hypertension, hyperlipidemia, and obesity. These conditions underlie the pathophysiology of metabolic syndrome (MetS). Hypogonadism, or testosterone deficiency (TD), is an integral component of the pathology underlying endothelial dysfunction and MetS, with insulin resistance (IR) at its core. Testosterone replacement therapy for TD has been shown to ameliorate some of the components of the MetS, improve IR, and may serve as treatment for decreasing cardiovascular and ED risk.
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