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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes

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[Associated antimicrobial resistance in Enterococcus spp. clinical isolates].

Cláudia Castelo Branco Artiaga Kobayashi¹, Geraldo Sadoyama, José Daniel Gonçalves Vieira

¹Laboratório de Microbiologia, Hospital de Urgências de Goiânia, Goiânia, GO.

Revista Da Sociedade Brasileira De Medicina Tropical

|June 1, 2011

Summary

Vancomycin-resistant enterococci (VRE) show linked resistance to crucial antibiotics like ampicillin and linezolid, limiting treatment options. This highlights the urgent need for new strategies against VRE infections in hospitals.

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Published on: July 9, 2012

Area of Science:

Clinical microbiology
Infectious diseases
Antimicrobial resistance

Context:

Rising hospital-acquired enterococci infections.
Vancomycin-resistant enterococci (VRE) present significant treatment challenges.
Limited efficacy of current antimicrobial therapies for enterococcal infections.

Purpose:

To investigate in vitro antimicrobial susceptibility of Enterococcus spp. isolates.
To evaluate the association of resistance between key antimicrobial agents against VRE.
To determine the relative risk of co-resistance.

Summary:

25.6% of 156 enterococci isolates were multidrug-resistant.
12 isolates (7.7%) were vancomycin-resistant enterococci (VRE).
VRE isolates exhibited high co-resistance to ampicillin (100%), streptomycin (90.9%), rifampin (91.7%), and linezolid (50%).

Impact:

Demonstrates significant associated resistance to first-choice and alternative antimicrobials for VRE.
Reveals a narrowing of therapeutic options in the studied institution.
Underscores the critical need for novel treatment strategies against VRE.