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Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Infection II: Pathophysiology01:25

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The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...

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Updated: Jun 1, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Acute tubulointerstitial nephritis.

Tim Ulinski1, Anne-Laure Sellier-Leclerc, Elena Tudorache

  • 1Department of Pediatric Nephrology, Armand Trousseau Hospital (APHP), University Pierre & Marie Curie, Paris 6, 26, Avenue du Docteur Arnold Netter, 75012, Paris, France. tim.ulinski@trs.aphp.fr

Pediatric Nephrology (Berlin, Germany)
|June 4, 2011
PubMed
Summary
This summary is machine-generated.

Acute tubulointerstitial nephritis (TIN), often caused by medications like NSAIDs and antibiotics, is a growing cause of acute kidney injury. Prompt treatment and avoiding triggers can lead to recovery, but chronic cases may develop.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
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Published on: November 10, 2021

Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Acute tubulointerstitial nephritis (TIN) is a significant cause of acute kidney injury.
  • It is characterized by inflammatory cell infiltration in the kidney interstitium.
  • Medication-induced immuno-allergic reactions, particularly to NSAIDs and antibiotics, are the leading etiologies.

Purpose of the Study:

  • To summarize the current understanding of acute tubulointerstitial nephritis (TIN).
  • To highlight the increasing incidence and common causes of TIN.
  • To outline diagnostic and therapeutic approaches for TIN.

Main Methods:

  • Review of existing literature on acute tubulointerstitial nephritis.
  • Analysis of etiological factors, clinical presentation, and outcomes.
  • Emphasis on diagnostic criteria and treatment strategies.

Main Results:

  • TIN incidence is rising, particularly in children, linked to NSAID overuse and prescription patterns.
  • NSAIDs and antibiotics are the most frequent culprits, though infections, toxins, and vasculitis can also induce TIN.
  • Spontaneous recovery is common, and prognosis is generally good with avoidance of the causal agent and prompt steroid therapy.

Conclusions:

  • Acute tubulointerstitial nephritis requires prompt recognition and management.
  • Adherence to guidelines for NSAID and antibiotic use is crucial for prevention.
  • While often reversible, the potential for progression to chronic TIN necessitates careful monitoring.