Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing subtle brain injury related to cognitive impairment in obese pediatric obstructive sleep apnea using 3D MRI texture analysis.

Scientific reports·2026
Same author

Assessment of Angiopep-2 targeting intracerebral α-synuclein aggregates in a PFF-induced rat model of Parkinson's disease based on 7T CEST-MRI.

Brain research bulletin·2026
Same author

Intracranial vessel wall MRI to identify the culprit aneurysm in subarachnoid hemorrhage with multiple intracranial aneurysms.

Emergency radiology·2026
Same author

Persistent Steal Physiology during a Ramp Cerebrovascular Reactivity Assessment Correlates with Severe Cortical Thinning in Steno-Occlusive Disease.

AJNR. American journal of neuroradiology·2025
Same author

MRI-Based Classification of Cerebral Hemodynamic Failure With Resting Perfusion Metrics and Cerebrovascular Reactivity.

Stroke·2025
Same author

Characterizing the evolution of lesion, penumbra and blood-brain barrier permeability in a photothrombotic juvenile rat stroke model using MRI and histology.

Scientific reports·2025
Same journal

Understanding Acute Encephalopathy.

Neuroimaging clinics of North America·2026
Same journal

Imaging of Acute Encephalopathies.

Neuroimaging clinics of North America·2026
Same journal

Pediatric Encephalopathy: Inflammatory and Autoimmune Etiologies.

Neuroimaging clinics of North America·2026
Same journal

Pediatric Encephalopathy: Inherited Metabolic Disorders.

Neuroimaging clinics of North America·2026
Same journal

Post-Treatment Causes of Encephalopathy.

Neuroimaging clinics of North America·2026
Same journal

Acute Toxic Leukoencephalopathy: Opioid and other Illicit or Abused Drugs and Environmental Toxins.

Neuroimaging clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Measuring permeability in acute ischemic stroke.

Andrea Kassner1, Daniel M Mandell, David J Mikulis

  • 1Department of Medical Imaging, University of Toronto, 150 College Street, Room 125, Toronto, ON M5S 3E2, Canada. andrea.kassner@utoronto.ca

Neuroimaging Clinics of North America
|June 7, 2011
PubMed
Summary
This summary is machine-generated.

The blood-brain barrier (BBB) prevents substances from entering the brain. Imaging techniques like CT and MRI can assess BBB integrity, crucial for understanding stroke complications.

More Related Videos

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
04:32

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples
04:32

Measuring Post-Stroke Cerebral Edema, Infarct Zone and Blood-Brain Barrier Breakdown in a Single Set of Rodent Brain Samples

Published on: October 23, 2020

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
09:59

A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia

Published on: September 16, 2017

Area of Science:

  • Neurology
  • Radiology
  • Vascular Biology

Background:

  • The blood-brain barrier (BBB) protects the brain by restricting substance entry.
  • Loss of BBB integrity is linked to hemorrhagic transformation in acute ischemic stroke.

Purpose of the Study:

  • To evaluate methods for assessing blood-brain barrier integrity.
  • To understand the role of BBB integrity in acute ischemic stroke.

Main Methods:

  • Qualitative assessment of contrast enhancement on CT and MR imaging.
  • Quantitative analysis using dynamic contrast-enhanced (DCE) MRI or CT with pharmacokinetic modeling.

Main Results:

  • CT and MR imaging detect BBB integrity by identifying contrast leakage.
  • Dynamic contrast-enhanced techniques allow for quantification and spatial mapping of BBB integrity.

Conclusions:

  • Imaging plays a vital role in evaluating BBB integrity.
  • Quantitative imaging methods offer detailed insights into BBB status, particularly in stroke scenarios.