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Related Experiment Videos

How maize transposable elements escape negative selection.

A Gierl1

  • 1Max-Planck-Institut für Züchiungs-Forschung, Abteilung Molekulare Pflanzengenetik, Köln, FRG.

Trends in Genetics : TIG
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

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Transposable elements like En/Spm and Ac influence gene expression and structure. Some elements mimic introns, reducing harmful mutations and aiding their evolutionary survival.

Area of Science:

  • Genetics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Transposable elements (TEs) are mobile genetic sequences that can alter gene structure and expression.
  • The En/Spm and Ac families of TEs are known to impact host genomes.
  • Insertional mutagenesis by TEs can have detrimental effects on organisms.

Purpose of the Study:

  • To investigate the mechanisms by which En/Spm and Ac transposable elements interact with host genes.
  • To understand how TEs might mitigate the negative consequences of insertional mutagenesis.
  • To explore the evolutionary implications of TE behavior and host interactions.

Main Methods:

  • Analysis of gene structure and expression in the presence of En/Spm and Ac elements.
  • Comparative genomics to identify TE sequences that resemble host introns.

Related Experiment Videos

  • Investigating the regulatory mechanisms controlling TE transposition activity.

    • Main Results:

    • Certain En/Spm and Ac elements share sequence and structural similarities with introns.
    • These intron-mimicking TEs can reduce the deleterious effects of insertional mutagenesis.
    • Evidence suggests multilevel control over TE transposition rates.

    Conclusions:

    • The intron-like nature of some TEs provides a mechanism to reduce harmful mutations.
    • Multilevel regulation of transposition contributes to the persistence of these elements.
    • These interactions offer insights into the long-term evolutionary 'survival' strategies of transposable elements.