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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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HIV and HAART-Associated Dyslipidemia
Eoin R Feeney1, Patrick W G Mallon
1HIV Molecular Research Group, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland.
The Open Cardiovascular Medicine Journal
|June 7, 2011
Summary
Highly active antiretroviral therapy (HAART) improves HIV survival but can cause dyslipidemia, increasing cardiovascular disease risk. This review covers HIV and ART-associated dyslipidemia, its causes, and management strategies.
Area of Science:
- Infectious Diseases
- Cardiology
- Pharmacology
Background:
- Highly active antiretroviral therapy (HAART) has significantly improved life expectancy for individuals with human immunodeficiency virus type 1 (HIV).
- Despite HAART's success, HIV-infected patients face increased morbidity and mortality from non-AIDS conditions, notably premature cardiovascular disease, liver, and renal failure.
- Dyslipidemia is a primary driver of elevated cardiovascular disease risk in HIV-infected patients, linked to aging, long-term HIV infection, and antiretroviral therapy (ART).
Purpose of the Study:
- To review the clinical presentation of dyslipidemia associated with HIV infection and ART.
- To elucidate the pathophysiology of HIV and ART-associated dyslipidemia, including links to specific antiretroviral medications.
- To propose evidence-based screening and management strategies for dyslipidemia in the context of HIV and ART.
Main Methods:
- This is a review article synthesizing current knowledge on HIV and ART-associated dyslipidemia.
- Literature search and analysis focusing on clinical presentation, pathophysiology, and treatment of dyslipidemia in HIV-infected patients.
- Examination of associations between specific antiretroviral drugs and dyslipidemia development.
Main Results:
- Dyslipidemia is a prevalent complication in HIV-infected individuals undergoing ART.
- Specific antiretroviral medications are associated with different patterns and severity of dyslipidemia.
- The pathophysiology involves complex interactions between HIV, ART, and host factors contributing to premature cardiovascular disease.
Conclusions:
- HIV and ART-associated dyslipidemia is a significant clinical challenge requiring vigilant monitoring.
- Understanding the specific drug-associated risks is crucial for personalized treatment and prevention strategies.
- Effective screening and management protocols are essential to mitigate cardiovascular risk in this growing patient population.
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