Asymmetric synthesis of the core structure of leucosceptroids A-D
Jun Xie1, Yuelong Ma, David A Horne
1Department of Molecular Medicine, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.
The Journal of Organic Chemistry
|June 8, 2011
Abstract:
The asymmetric synthesis of the core structure of leucosceptroids A-D has been achieved. The key steps of the synthesis includes the formation of the cis-2,5-disubstituted THF ring by TPAP catalytic oxidative cyclization followed by a highly diastereoselective intramolecular Diels-Alder reaction to fashion the fused tricyclic hydrindane ring system.
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