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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...

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Related Experiment Video

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Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
07:55

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

[Rare primary chest wall sarcoma: the synovialosarcoma].

L Fekih1, L Boussoffara, S Fenniche

  • 1Service de Pneumologie Ibn Nafiss, Hôpital Abderrahmen Mami Ariana, Tunisie. leila.fekih@laposte.net

Revue Des Maladies Respiratoires
|June 8, 2011
PubMed
Summary

This case study highlights a rare parietal synovialosarcoma of the chest wall. While initially responsive to chemotherapy and radiotherapy, the patient ultimately succumbed to pulmonary embolism, underscoring the aggressive nature of this thoracic malignancy.

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Pathology

Background:

  • Malignant thoracic tumors encompass a diverse group originating from lung, mediastinal, pleural, or chest wall structures.
  • Chest wall tumors represent a significant subset requiring accurate diagnosis and tailored treatment strategies.

Observation:

  • A 37-year-old presented with chest pain and palpable chest wall masses.
  • Imaging revealed a large chest wall mass invading the mediastinum and a second mass on the right ribs.
  • Biopsy confirmed the diagnosis of parietal synovialosarcoma.

Findings:

  • The patient demonstrated initial positive response to ifosfamide and doxorubicin chemotherapy and mediastino-pulmonary radiotherapy.
  • Despite clinical and radiological improvement, the patient experienced a fatal pulmonary embolism.

Implications:

  • Chest wall synovialosarcoma carries a poor prognosis, necessitating aggressive management.
  • The observed chemosensitivity suggests potential for initial treatment efficacy, though long-term outcomes remain challenging.
  • This case underscores the critical importance of early detection and multidisciplinary care for rare thoracic malignancies.