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Updated: Jun 1, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
Published on: January 16, 2016
Modeling of chemical reactions in micelle: water-mediated keto-enol interconversion as a case study
Paolo Marracino1, Andrea Amadei, Francesca Apollonio
1Dipartimento di Ingegneria dell'Informazione, Elettronica e Telecomunicazioni, Universita' di Roma La Sapienza, Roma, Italia.
Abstract:
The effect of a zwitterionic micelle environment on the efficiency of the keto-enol interconversion of 2-phenylacetylthiophene has been investigated by means of a joint application of experimental and theoretical/computational approaches. Results have revealed a reduction of the reaction rate constant if compared with bulk water essentially because of the different solvation conditions experienced by the reactant species, including water molecules, in the micelle environment. The slight inhibiting effect due to the application of a static electric field has also been theoretically investigated and presented.
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