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Updated: Jun 1, 2026

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis
Published on: July 28, 2023
The challenges of developing new tuberculosis vaccines
Lewellys F Barker1, Annmarie E Leadman, Bartholt Clagett
1Aeras, Rockville, Maryland, USA.lbarker@aeras.org
Abstract:
The World Health Organization estimates that tuberculosis is causing nearly two million deaths annually, mostly in developing countries. Widespread administration of the current tuberculosis vaccine to newborns is not a reliable route for preventing the disease in adults, the population that drives the epidemic. Several new vaccine candidates are in development, and a few have entered clinical trials. However, the field faces formidable scientific and policy challenges. A collaborative approach to solving scientific, policy, and resource obstacles--as well as new partnerships among emerging economies and vaccine development organizations--will be critical to developing a new tuberculosis vaccine that could achieve its public health potential to save lives and reduce the burden of disease.
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