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06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Molecular basis of chronopharmaceutics
Shigehiro Ohdo1, Satoru Koyanagi, Naoya Matsunaga
1Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan. ohdo@phar.kyushu-u.ac.jp
Journal of Pharmaceutical Sciences
|June 10, 2011
Summary
Biological rhythms influence health and disease. Understanding chronopharmacology, the study of how drug timing affects pharmacokinetics and pharmacodynamics, can optimize treatment effectiveness and safety.
Area of Science:
- Chronobiology
- Pharmacology
- Genetics
Background:
- Physiological processes, including metabolism and sleep-wake cycles, exhibit 24-hour biological rhythms.
- Disruptions in these circadian variations can trigger or worsen diseases.
- Chronotherapeutics, optimizing drug efficacy and safety through timed administration, is a growing field.
Purpose of the Study:
- To review the biological rhythm regulatory systems.
- To explore the application of chronobiology in pharmaceutics.
- To examine the impact of Clock gene variability on drug pharmacokinetics and pharmacodynamics.
Main Methods:
- Review of existing literature on circadian rhythms, chronopharmacology, and Clock genes.
- Analysis of the molecular mechanisms underlying circadian regulation.
- Discussion of intra- and inter-individual variations in Clock gene expression.
Main Results:
- The suprachiasmatic nucleus acts as the mammalian circadian pacemaker, regulated by Clock genes.
- CLOCK mutations affect gene expression, leading to phenotypic changes impacting drug parameters.
- Both pharmacodynamics and pharmacokinetics of drugs are influenced by circadian rhythms.
Conclusions:
- Chronopharmacological principles are crucial for personalized medicine.
- Understanding Clock gene variability can lead to tailored drug therapies.
- Optimizing drug delivery timing based on biological rhythms enhances therapeutic outcomes.
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