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Related Experiment Video

Updated: Jun 1, 2026

A Swine Model of Neonatal Asphyxia
10:36

A Swine Model of Neonatal Asphyxia

Published on: October 11, 2011

Perinatal asphyxia in a nonhuman primate model.

Elizabeth N Jacobson Misbe1, Todd L Richards, Ronald J McPherson

  • 1Department of Pediatrics, University of Washington, Seattle, WA 98195-6320, USA.

Developmental Neuroscience
|June 11, 2011
PubMed
Summary
This summary is machine-generated.

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Perinatal asphyxia in nonhuman primates, induced by umbilical cord occlusion, causes significant neonatal brain injury and long-term deficits. This study models these effects to aid in developing new treatments for hypoxic-ischemic encephalopathy.

Area of Science:

  • Neuroscience
  • Neonatal Research
  • Primate Models

Background:

  • Perinatal asphyxia is a major cause of neonatal brain injury with limited treatments.
  • Nonhuman primates offer a relevant model for preclinical neurotherapeutic testing due to physiological similarities.
  • Previous work established a primate model using 12-15 minutes of umbilical cord occlusion.

Purpose of the Study:

  • To evaluate increased morbidity from 18 minutes of umbilical cord occlusion in a primate model.
  • To compare outcomes between control and asphyxiated pigtail macaques over 9 months.
  • To characterize acute and chronic consequences of perinatal asphyxia and identify imaging/developmental outcome measures.

Main Methods:

  • Pigtail macaques underwent hysterotomy after 0, 15, or 18 minutes of umbilical cord occlusion, followed by resuscitation.

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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

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Last Updated: Jun 1, 2026

A Swine Model of Neonatal Asphyxia
10:36

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Published on: October 11, 2011

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
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A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation
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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

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  • Biochemical, physiological, behavioral, developmental, and MRI data were collected over 9 months.
  • Diagnostic imaging and neurodevelopmental tests were used to quantify injury and outcomes.

    • Main Results:

    • All asphyxiated animals showed signs of hypoxic-ischemic encephalopathy at birth, including metabolic acidosis and reduced brain activity.
    • Asphyxiated animals exhibited biochemical and clinical indicators of brain injury.
    • Long-term physical and cognitive deficits were observed in asphyxiated subjects compared to controls.

    Conclusions:

    • An 18-minute umbilical cord occlusion in pigtail macaques reliably induces perinatal asphyxia with significant acute and chronic consequences.
    • This enhanced primate model allows for detailed characterization of neonatal brain injury.
    • The study validates imaging and neurodevelopmental assessments for evaluating therapeutic interventions in neonatal brain injury.