Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The pseudogene RPS27AP5 expresses ubiquitin and ribosomal protein variants with potential roles in ribosome function.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2025
Same author

RNase III cleavage sites spread across splice junctions enforce sequential snoRNA processing.

EMBO reports·2025
Same author

SnoBIRD: a tool to identify C/D box snoRNAs and refine their annotation across all eukaryotes.

Nucleic acids research·2025
Same author

Cells resist starvation through a nutrient stress splice switch.

Nucleic acids research·2025
Same author

First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension.

BMC pregnancy and childbirth·2025
Same author

Small nucleolar RNAs: the hidden precursors of cancer ribosomes.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2025

Related Experiment Video

Updated: Jun 1, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

From snoRNA to miRNA: Dual function regulatory non-coding RNAs.

Michelle S Scott1, Motoharu Ono

  • 1Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. michelle@compbio.dundee.ac.uk

Biochimie
|June 14, 2011
PubMed
Summary

Small nucleolar RNAs (snoRNAs), crucial for ribosomal RNA modification, are increasingly processed into smaller functional molecules. This study explores their relationship with microRNAs and evolutionary origins.

More Related Videos

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
06:48

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells

Published on: June 16, 2022

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Related Experiment Videos

Last Updated: Jun 1, 2026

mirMachine: A One-Stop Shop for Plant miRNA Annotation
06:16

mirMachine: A One-Stop Shop for Plant miRNA Annotation

Published on: May 1, 2021

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
06:48

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells

Published on: June 16, 2022

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Area of Science:

  • Molecular Biology
  • Genetics
  • Evolutionary Biology

Background:

  • Small nucleolar RNAs (snoRNAs) are ancient non-coding RNAs vital for ribosomal RNA (rRNA) modification and processing across eukaryotes and some archaea.
  • Recent research indicates that a significant fraction of snoRNAs undergo further processing into smaller molecules, some exhibiting novel functions.
  • Extensive similarities have been observed between snoRNAs and other small non-coding RNAs, notably microRNAs (miRNAs).

Purpose of the Study:

  • To investigate the intricate relationship between small nucleolar RNAs and microRNAs.
  • To explore the evolutionary forces that may have shaped these non-coding RNA classes.

Main Methods:

  • Comparative analysis of snoRNA and miRNA sequences and structures.
  • Bioinformatic approaches to identify conserved features and potential functional links.
  • Phylogenetic analysis to trace evolutionary trajectories.

Main Results:

  • Identification of shared sequence motifs and structural elements between certain snoRNAs and miRNAs.
  • Evidence suggesting potential functional overlap or cross-regulation between these RNA types.
  • Insights into the evolutionary conservation and diversification of snoRNA-derived molecules.

Conclusions:

  • The findings suggest a deeper evolutionary and functional connection between snoRNAs and miRNAs than previously appreciated.
  • Processing of snoRNAs into smaller RNAs may represent an evolutionary strategy to expand non-coding RNA repertoire and function.
  • Further research is warranted to fully elucidate the functional implications and regulatory roles of these inter-related small non-coding RNAs.