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Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Comparing measles with previous eradication programs: enabling and constraining factors.

Robert Keegan1, Alya Dabbagh, Peter M Strebel

  • 1Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.

The Journal of Infectious Diseases
|June 14, 2011
PubMed
Summary
This summary is machine-generated.

Measles eradication is feasible but challenging, requiring significant political and societal support. Lessons from past disease eradication programs highlight key factors for success and potential obstacles.

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Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

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Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes
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Preventing the Spread of Malaria and Dengue Fever Using Genetically Modified Mosquitoes

Published on: July 4, 2007

Area of Science:

  • Global Health
  • Epidemiology
  • Public Health Policy

Background:

  • Historical analysis of five major disease eradication programs from the late 20th century.
  • Identification of enabling and constraining factors (political, social, economic) influencing program success.

Purpose of the Study:

  • To inform decision-making for a proposed measles eradication initiative.
  • To compare historical eradication efforts with the potential for measles eradication.

Main Methods:

  • Literature review of yaws, malaria, smallpox, guinea worm, and polio eradication programs.
  • Comparative analysis of enabling and constraining factors across programs.

Main Results:

  • Measles eradication offers advantages: strong political/societal support, cost-effectiveness, validated feasibility.
  • Challenges include population density, urbanization, and conflict.

Conclusions:

  • Measles eradication is challenging, though potentially less so than polio eradication.
  • Success hinges on adequate resources and commitment to address political, social, economic, and technical hurdles.