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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jun 1, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Anaphylaxis pathogenesis and treatment.

F Estelle R Simons1

  • 1University of Manitoba, Winnipeg, MB, Canada. simons@cc.umanitoba.ca

Allergy
|June 15, 2011
PubMed
Summary
This summary is machine-generated.

Anaphylaxis, a severe allergic reaction, requires prompt epinephrine treatment. Research focuses on new biomarkers, risk assessment, and improving evidence for anaphylaxis management to prevent fatal outcomes.

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Related Experiment Videos

Last Updated: Jun 1, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Area of Science:

  • Allergy and Immunology
  • Clinical Translational Research

Background:

  • Anaphylaxis is a life-threatening allergic reaction with rapid onset.
  • Current diagnosis relies on clinical criteria; delayed epinephrine treatment increases fatality risk.
  • Understanding severe anaphylaxis requires research into mechanisms, triggers, and risk factors.

Purpose of the Study:

  • To review translational research in anaphylaxis.
  • Focus areas include novel biomarkers for diagnosis, differentiating sensitization from clinical risk, the role of epinephrine, and evidence base enhancement.

Main Methods:

  • Review of current translational research in anaphylaxis.
  • Analysis of studies on biomarkers, diagnostic tests, and treatment efficacy.
  • Focus on epinephrine's critical role and evidence strengthening.

Main Results:

  • Potential for new biomarkers to aid anaphylaxis diagnosis.
  • Development of tests to distinguish allergen sensitization from clinical risk.
  • Emphasis on epinephrine as the primary, crucial treatment.

Conclusions:

  • Advancing research in anaphylaxis diagnosis and treatment is vital.
  • Improved understanding and evidence are needed to reduce severe and fatal reactions.
  • Epinephrine remains the cornerstone of anaphylaxis management.