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Updated: Jun 1, 2026

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Published on: May 24, 2016
Failure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog
Manuel Martin-Flores1, Jordyn Boesch, Luis Campoy
1Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Abstract:
A case of prolonged muscle relaxation after vecuronium in an anesthetized dog is presented. After using peripheral nerve stimulation to confirm partial recovery of neuromuscular transmission, administration of 0.5 mg/kg IV of intravenous edrophonium failed to complete the reversal process. Subsequent administration of neostigmine resulted in complete recovery from blockade. Without monitoring neuromuscular function with a peripheral nerve stimulator until reversal was complete, it was very likely this patient would have been extubated with incomplete neuromuscular transmission. Several factors affecting the duration of neuromuscular blockade and its reversal are addressed.
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