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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

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Related Experiment Video

Updated: Jun 1, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

26. Pain in chronic pancreatitis.

Martine Puylaert1, Leonardo Kapural, Jan Van Zundert

  • 1Department of Anesthesiology and Multidisciplinary Pain Centre, Ziekenhuis Oost-Limburg, Genk, Belgium.

Pain Practice : the Official Journal of World Institute of Pain
|June 17, 2011
PubMed
Summary

Chronic pancreatitis causes irreversible pancreatic damage and severe pain. Management involves lifestyle changes, WHO ladder analgesics, and interventional therapies like radiofrequency or spinal cord stimulation.

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Area of Science:

  • Gastroenterology and Pain Management

Background:

  • Chronic pancreatitis involves progressive inflammation leading to irreversible pancreatic damage.
  • Pain is a significant symptom, often difficult to manage due to incompletely understood pathogenesis.

Purpose of the Study:

  • To review current and potential treatment strategies for chronic pancreatitis pain.
  • To evaluate the role of pharmacological and interventional pain management.

Main Methods:

  • Review of existing literature on chronic pancreatitis pain management.
  • Discussion of pharmacological approaches based on the WHO analgesic ladder.
  • Exploration of interventional techniques including radiofrequency ablation, spinal cord stimulation, endoscopic procedures, and surgery.

Main Results:

  • Pharmacological management follows the WHO three-step ladder, often supplemented with co-analgesics.
  • Interventional options include radiofrequency treatment, spinal cord stimulation, endoscopic interventions, and surgery.
  • While randomized controlled trials are lacking for some interventional methods, published series support their consideration.

Conclusions:

  • Effective pain management in chronic pancreatitis requires a multimodal approach.
  • Less invasive interventions like radiofrequency treatment may be considered before more invasive options.
  • Further research is needed to establish definitive evidence for interventional therapies.