Prolonged P wave dispersion in pre-diabetic patients
Turgut Karabag1, Mustafa Aydin, Sait M Dogan
1Department of Cardiology, Faculty of Medicine, Karaelmas University, Zonguldak, Turkey. turgutkarabag@yahoo.com
Kardiologia Polska
|June 17, 2011
Summary
Pre-diabetes is associated with increased P wave duration and dispersion, indicating atrial electrical changes. These findings suggest potential early cardiac risks in individuals with pre-diabetes.
Area of Science:
- Cardiology
- Endocrinology
- Electrophysiology
Background:
- Overt diabetes and chronic hyperglycemia are known risk factors for atrial fibrillation.
- P wave dispersion (PWD) quantifies heterogeneity in atrial refractoriness.
Purpose of the Study:
- To investigate P wave dispersion (PWD) in patients diagnosed with pre-diabetes.
- To assess potential early electrophysiological changes in pre-diabetic individuals.
Main Methods:
- 84 pre-diabetic patients and 48 healthy controls underwent standard 12-lead electrocardiography.
- P wave durations were measured to calculate maximum (Pmax) and minimum (Pmin) P wave durations.
- P wave dispersion (PWD) was calculated as the difference between Pmax and Pmin.
Main Results:
- Pre-diabetic patients exhibited significantly higher Pmax and PWD compared to healthy controls.
- A positive correlation was observed between PWD and fasting blood glucose levels.
- No significant correlation was found between PWD and HbA1c levels, age, or cardiac structural parameters.
Conclusions:
- Increased P wave duration and dispersion are present in pre-diabetic patients without overt cardiovascular disease.
- These findings suggest that pre-diabetes may be associated with early atrial electrical remodeling.
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