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Direct Mouse Trauma/Burn Model of Heterotopic Ossification
07:01

Direct Mouse Trauma/Burn Model of Heterotopic Ossification

Published on: August 6, 2015

Sensory nerve induced inflammation contributes to heterotopic ossification

Elizabeth Salisbury1, Eric Rodenberg, Corinne Sonnet

  • 1Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.

Journal of Cellular Biochemistry
|June 17, 2011
PubMed
Summary

Bone morphogenetic proteins (BMPs) trigger neuroinflammation and heterotopic ossification (HO) following injury. Blocking neuroinflammation significantly reduces HO, indicating a role for nerves and stem cells in bone formation.

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