[Correlation study on different dyslipidemia classification and glucose metabolism in patients with hyperlipidemia]

To detect the impaired glucose metabolism in dyslipidemic patients and explore whether the type of dyslipidemia affects the type of impaired glucose metabolism.

In our study, 197 patients without diabetes or cardiovascular disease history were divided into 4 groups according to fasting serum lipid levels: hypercholesterolemic group (HCh group, 45 patients); hypertriglyceridemic group (HTG group, 46 patients); combined dyslipidemic group (58 patients) and control group (48 patients). Serum insulin and glucose levels were detected in fasting situation. HOMA-IR was calculated. And then the patients received 75 g oral glucose tolerance test (OGTT) and their GLU120 levels were detected.

The GLU120 levels in HTG group [(10.5±3.2) mmol/L] and combined dyslipidemic group [(12.0±5.4) mmol/L] were significantly higher than those in control group [(8.7±3.5) mmol/L, P=0.045 and 0.024, respectively]. HTG group (39.1%) and combined dyslipidemic group (31.0%) also had higher impaired glucose tolerance (IGT) incidence ratios than those in control group (22.9%, P=0.009 and 0.014, respectively). In subgroup study of patients with fasting glucose levels below 6.1 mmol/L, the incidence ratios of IGT in HTG group and combined dyslipidemic group were 51.4% and 43.9%, respectively, which were significantly higher than those in control group (29.7%, P=0.009 and 0.015, respectively).

There exists a definite ratio of undiscovered impaired glucose metabolism in dyslipidemic patients who have not suffered from cardiovascular disease, especially in hypertriglyceridemic and combined dyslipidemic group. OGTT is suggested to be brought into effect in order that impaired glucose metabolism would be detected in earlier stage.