Related Experiment Video
Updated: Jul 23, 2026

Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts
Published on: January 2, 2018
Optimization of filtration for reduction of lung dose from Rn decay products: Part I--Theoretical
C A Curling1, S N Rudnick, P B Ryan
1Harvard School of Public Health, Physical Sciences and Engineering Program, Boston, MA 02115.
Abstract:
A theoretical model was developed for the optimization of filter characteristics that would minimize the dose from the inhalation of Rn decay products. Modified forms of the Jacobi-Porstendorfer room model and the Jacobi-Eisfeld lung dose model were chosen for use in the mathematical simulation. Optimized parameters of the filter were the thickness, solidity, and fiber diameter. For purposes of the calculations, the room dimensions, air exchange rate, particle-size distribution and concentration, and the Rn concentration were specified. The resulting computer-aided optimal design was a thin filter (the minimum thickness used in the computer model was 0.1 mm) having low solidity (the minimum solidity used was 0.5%) and large diameter fibers (the maximum diameter used was 100 microns). The simulation implies that a significant reduction in the dose rate can be achieved using a well-designed recirculating filter system. The theoretical model, using the assumption of ideal mixing, predicts an 80% reduction in the dose rate, although inherent in this assumption is the movement of 230 room volumes per hour through the fan.

