Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Patients With Relapsing Multiple Sclerosis Switching to Ocrelizumab Due to Suboptimal Treatment Response: Results of the 4-Year CASTING-LIBERTO Trial.

European journal of neurology·2026
Same author

Binary partitioning of human brain organization due to divergent human cytoskeletal evolution.

bioRxiv : the preprint server for biology·2026
Same author

Ultra-low-field MRI for bedside imaging of severe multiple sclerosis.

Journal of neurology·2026
Same author

Increased functional network connectivity following cognitive rehabilitation in progressive multiple sclerosis with moderate to severe disabilty: findings from the CogEx study.

Journal of neurology·2026
Same author

Looking Beyond Dose: Identifying Responders and Non-Responders to RehaCom Computerized Cognitive Rehabilitation in Progressive MS-The CogEx Study.

Neurorehabilitation and neural repair·2026
Same author

Acute Aerobic Walking Exercise Induces Changes in Thalamic Resting-State Connectivity in Persons with Multiple Sclerosis.

Medicine and science in sports and exercise·2026

Related Experiment Video

Updated: May 31, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Cognitive dysfunction and multiple sclerosis: developing a rationale for considering the efficacy of exercise

Robert W Motl1, Brian M Sandroff, Ralph H B Benedict

  • 1Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. robmotl@illinois.edu

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 21, 2011
PubMed
Summary
This summary is machine-generated.

Exercise training may improve cognitive function in multiple sclerosis (MS). Future research should explore this potential, drawing from gerontology to benefit individuals with MS.

More Related Videos

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

Related Experiment Videos

Last Updated: May 31, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
10:19

Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

Published on: August 22, 2014

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Science

Background:

  • Cognitive impairment is a significant and poorly managed issue in multiple sclerosis (MS).
  • Exercise training is a potential non-pharmacological intervention for managing MS-related cognitive deficits.
  • Existing evidence suggests exercise benefits cognition in older adults and impacts mobility and quality of life in both older adults and MS patients.

Purpose of the Study:

  • To highlight the need for further research into the effects of exercise training on cognitive function in individuals with MS.
  • To advocate for the adoption of gerontological research methodologies in future studies.

Main Methods:

  • Literature review and meta-analysis of studies on exercise, physical activity, aerobic fitness, and cognitive function.
  • Analysis of existing cross-sectional studies on exercise and cognition in MS.
  • Proposal for future randomized controlled trials (RCTs) incorporating gerontological practices.

Main Results:

  • Aerobic fitness, physical activity, and exercise are linked to better cognitive function in older adults.
  • Exercise training demonstrates comparable effects on mobility and quality of life in older adults and persons with MS.
  • Current research on exercise and cognition in MS is preliminary, primarily using cross-sectional designs.

Conclusions:

  • Exercise training warrants consideration as an intervention for cognitive impairment in MS.
  • Future randomized controlled trials (RCTs) are needed to establish causality and optimal protocols.
  • Integrating gerontological research methods can enhance the rigor and impact of studies on exercise and cognition in MS.