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Updated: May 31, 2026

Synchronous Triplanar Reconstruction Integrated with Color Doppler Mapping for Precise and Rapid Localization of Thyroid Lesions
Published on: February 9, 2024
Thyroid swelling in a 32-year-old male
Manoj Pandey1, Vinay Kumar, Mridula Shukla
1Institute of Medical Sciences, Surgical Oncology, Banaras Hindu University, Varanasi, UP, 221005, India.
Intrathyroidal metastasis, a rare finding, can originate from stomach cancer, especially in patients with Peutz-Jeghers polyposis. Early diagnosis of this rare metastatic presentation is crucial for effective treatment and avoiding unnecessary surgery.
Area of Science:
- Oncology
- Gastroenterology
- Endocrinology
Background:
- Intrathyroidal metastasis is uncommon, often presenting without a clear primary malignancy.
- Gastric carcinoma can metastasize to unusual sites, including the thyroid.
- Peutz-Jeghers polyposis is a rare genetic disorder associated with increased cancer risk.
Purpose of the Study:
- To report a unique case of intrathyroidal metastasis from gastric carcinoma.
- To highlight the association with Peutz-Jeghers polyposis.
- To emphasize the importance of high clinical suspicion for accurate diagnosis.
Main Methods:
- Case report of a 32-year-old male with thyroid swelling and abdominal pain.
- Fine-needle aspiration cytology of the thyroid swelling.
- Diagnostic work-up including metastatic evaluation and genetic assessment.
Main Results:
- Thyroid fine-needle aspiration revealed mucinous adenocarcinoma deposits.
- Primary site identified as diffuse gastric carcinoma.
- Metastases also found in the liver and retroperitoneal lymph nodes, associated with Peutz-Jeghers polyposis.
Conclusions:
- This is the first reported case of intrathyroidal metastasis from gastric carcinoma with Peutz-Jeghers polyposis presenting as a thyroid swelling.
- High suspicion and thorough evaluation are vital to avoid misdiagnosis and unnecessary thyroidectomy.
- Chemotherapy offers palliative benefits for disseminated disease.
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