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Updated: May 31, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Corneal crosslinking for progressive keratoconus in four children
Nienke Soeters1, Allegonda Van der Lelij, Rikkert van der Valk
1Department of Ophthalmology, HP E03.136, University Medical Center Utrecht, Heidelberglaan 100, 3508 GX Utrecht, The Netherlands. N.Soeters@umcutrecht.nl
Corneal crosslinking (CXL) offers a safe treatment for progressive keratoconus in children, potentially preventing the need for corneal transplants at a young age.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Pediatric Eye Care
Background:
- Keratoconus is a progressive eye condition causing thinning and bulging of the cornea.
- Current guidelines restrict corneal crosslinking (CXL) to patients aged 18 and older.
- Rapid progression of keratoconus in teenagers necessitates alternative treatment strategies.
Observation:
- This study details four pediatric cases of progressive keratoconus.
- All patients underwent corneal crosslinking (CXL) for treatment.
- The procedure was evaluated for safety and efficacy in this young demographic.
Findings:
- Corneal crosslinking (CXL) demonstrated a safe and effective treatment option for pediatric keratoconus.
- The treatment successfully halted disease progression in the observed cases.
- No significant adverse events were reported during or after the CXL procedure.
Implications:
- Corneal crosslinking (CXL) may be a viable option for younger keratoconus patients.
- Early intervention with CXL could prevent the need for corneal transplantation in adolescents.
- This approach could significantly improve long-term visual outcomes for pediatric keratoconus patients.
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