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Related Concept Videos

Golgi Apparatus

Golgi Apparatus

As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.

Golgi Apparatus

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...

Golgi Apparatus

Golgi Apparatus

Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...

Transport Across the Golgi

Transport Across the Golgi

While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...

Golgi Matrix Proteins

Golgi Matrix Proteins

Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...

Vesicular Tubular Clusters

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...

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Related Experiment Video

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Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

Published on: August 10, 2017

Golgi biogenesis.

Yanzhuang Wang¹, Joachim Seemann

¹Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA. yzwang@umich.edu

Cold Spring Harbor Perspectives in Biology

|June 22, 2011

Summary

This summary is machine-generated.

Mammalian Golgi ribbons disassemble into vesicles during mitosis for cell division and reassemble afterward. This review covers the molecular mechanisms driving Golgi disassembly and reassembly in dividing cells.

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Area of Science:

Cell Biology
Molecular Biology
Organelle Dynamics

Background:

The Golgi apparatus is a vital organelle in the eukaryotic secretory pathway.
In mammalian cells, the Golgi forms a continuous ribbon around the nucleus.
This ribbon structure presents challenges for inheritance during cell division.

Purpose of the Study:

To summarize the molecular mechanisms of Golgi dynamics during cell division.
To explain Golgi disassembly and reassembly in mammalian cells.

Main Methods:

Literature review of studies on mitotic Golgi.
Analysis of molecular pathways involved in organelle partitioning.

Main Results:

The mammalian Golgi ribbon disassembles into vesicles during early mitosis.
This process ensures proper segregation of Golgi components to daughter cells.
A functional Golgi is reformed after cell division.

Conclusions:

Understanding Golgi mitotic behavior is crucial for cell division.
Molecular mechanisms govern the cycle of Golgi disassembly and reassembly.