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Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts
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Published on: August 13, 2014

Continuous hypertonic saline for acute liver failure.

Ratender Kumar Singh1, Banani Poddar, Sanjay Singhal

  • 1Department of Critical Care Medicine, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. ratender@sgpgi.ac.in

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|June 23, 2011
PubMed
Summary
This summary is machine-generated.

Acute liver failure (ALF) poses a high mortality risk, often due to cerebral edema. This case study shows successful management of a pediatric patient with hepatitis A-induced ALF and severe hepatic encephalopathy using continuous hypertonic saline in the ICU.

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Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
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Area of Science:

  • Hepatology
  • Pediatric Critical Care
  • Neurology

Background:

  • Acute liver failure (ALF) is a severe clinical syndrome with significant mortality.
  • Cerebral edema is the primary cause of death in patients with ALF.
  • Hepatitis A is a potential cause of ALF, particularly in pediatric populations.

Observation:

  • A 12-year-old boy presented with hepatitis A-related ALF and grade IV hepatic encephalopathy.
  • The patient required intensive care unit (ICU) management for this critical condition.

Findings:

  • Continuous hypertonic saline was utilized as the primary osmotherapy.
  • This treatment approach led to successful management of the patient's condition.

Implications:

  • Continuous hypertonic saline may be an effective osmotherapy for managing cerebral edema in pediatric ALF.
  • This case highlights a potential treatment strategy for severe hepatic encephalopathy in the context of viral hepatitis-induced ALF.