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Recognition of thymine in DNA bulges by a Zn(II) macrocyclic complex
Imee Marie A del Mundo1, Matthew A Fountain, Janet R Morrow
1Department of Chemistry, University at Buffalo, State University of New York, Buffalo, NY, USA.
Abstract:
A Zn(II) macrocyclic complex with appended quinoline is a bifunctional recognition agent that uses both the Zn(II) center and the pendent aromatic group to bind to thymine in bulges with good selectivity over DNA containing G, C or A bulges. Spectroscopic studies show that the stem containing the bulge stays largely intact in a DNA hairpin with the Zn(II) complex bound to the thymine bulge.
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