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A novel HLA-DQB1*03:02 variant designated DQB1*03:02:05

K Todorova1, H Schulze, G Diederich

  • 1HLA Typing Laboratory, Charite Virchow Klinikum, Berlin, Germany. kremena.todorova@charite.de

Tissue Antigens
|June 29, 2011
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Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...