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New Nanomedicine Approaches Using Gold-thioguanine Nanoconjugates as Metallo-ligands
Lee Sleightholm1, Ajit Zambre, Nripen Chanda
1Department of Radiology, University of Missouri-Columbia, Columbia, MO 65212, USA.
Abstract:
Gold-thioguanine nanoconjugates (AuNP-TG) of size 3-4 nm were synthesized and the ratio between gold and 6-Thioguanine (TG) was estimated as ~1:1.5 using a cyanide digestion method and confirmed by flame atomic absorption spectroscopic analysis. AuNP-TG constructs showed high in vitro stability under different pH conditions and biologically relevant solutions for a period of 24 hours. Reaction of AuNP-TG with europium or platinum salts resulted in the formation of organized self-assembled metallo-networks.

