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Updated: May 10, 2025

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Origami Inspired Self-assembly of Patterned and Reconfigurable Particles

Published on: February 4, 2013

Self-Assembled Multilayered Concentric Supraparticle Architecture.

Agasthya Suresh^1,2,3, Dhananjay Suresh¹, Zhaohui Li¹

¹Department of Radiology, University of Missouri, Columbia, MO, 65212, USA.

Advanced Materials (Deerfield Beach, Fla.)

|April 26, 2025

Summary

This summary is machine-generated.

Researchers developed Self-Assembled Multilayered Supraparticles (SAMS) using gold nanoparticles, lipidoid, and gelatin. These novel supraparticles show promise for efficient in vivo delivery of therapeutic payloads like siRNA and mRNA.

Keywords:

RNA delivery multilayered self‐assembly supraparticles

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Area of Science:

Nanotechnology and Materials Science
Biomedical Engineering
Drug Delivery Systems

Background:

Supraparticles (SPs) are emerging as versatile platforms for catalysis, photonics, and medicine due to their unique properties.
Synthesizing novel SPs with complex internal structures presents a significant challenge in materials science.
Existing SPs often lack the intricate architectures required for advanced applications, particularly in nanomedicine.

Purpose of the Study:

To introduce a novel class of Self-Assembled Multilayered Supraparticles (SAMS) with complex internal structures.
To investigate the synergistic interactions between gold nanoparticles, lipidoid, and gelatin in SAMS formation.
To evaluate the potential of SAMS as a platform for efficient in vivo delivery of therapeutic nucleic acids.

Main Methods:

Fabrication of SAMS through a synergistic three-way interaction involving gold nanoparticles, lipidoid, and gelatin.
Characterization of SAMS structure, including concentric lamellar spherical architecture, interlayer spacing (3.5 ± 0.2 nm), and diameter (156.8 ± 56.6 nm).
Analysis of physical and chemical factors influencing SAMS formation, such as nanoparticle size, lipidoid chain length, and surface chemistry.

Main Results:

Successful synthesis of SAMS with controlled multilayered spherical structures.
Demonstration that SAMS formation is critically dependent on nanoparticle size, lipidoid chain length, and surface chemistry.
Efficient in vivo delivery of labile payloads, including siRNA, achieving dose-dependent gene silencing, with potential for mRNA delivery.

Conclusions:

This work introduces a novel supraparticle structure (SAMS) and a new interaction phenomenon for their formation.
SAMS exhibit tunable properties influenced by physical and chemical factors, enabling precise control over interparticle interactions.
SAMS demonstrate significant potential as an advanced nanomedicine platform for effective in vivo nucleic acid delivery.